Possible Interaction: Phosphatidic Acid and Phosphatidylethanolamine

“The lipids cholesteryl hemisuccinate, linoleamide/oleamide, and phosphatidylethanolamine inhibit and phosphatidic acid and sphingomyelin enhance SPCA1a activity.”

“In the presence of ethanol, phosphatidyl-ethanol is generated at the expense of PA leading to the suppression of mTOR.”

“The formation of PA was associated with a decrease in phosphatidylcholine (PC) and phosphatidylethanolamine ( PE).”

“Concomitant with phosphatidylethanol formation was a partial block of PA production.”

“Among the phospholipid classes phosphatidic acid decreased while phosphatidylethanolamine , phosphatidylcholine and phosphatidylserine increased rapidly, returning toward control values by 9 days.”

“On the basis of these results it is postulated that PA might increase the bilayer-destabilizing effects of PE , and hence increase the translocation efficiency of apocyt.c and its leakage-induction ability.”

“Binding of a primary amine to an anionic polar head of phosphatidic acid, such as in phosphatidylserine and phosphatidylethanolamine , slightly decreased the inhibitory effect of phosphatidic acid and, conversely, binding of a strong cation to the head, such as in phosphatidylcholine, resulted in its activation of chymase.”

“Acidic lipids phosphatidylserine and phosphatidic acid inhibited the activity of the enzyme incorporated into all of the phosphatidylethanolamines except when the enzyme was in soya PE in which the acidic lipids had no effect.”

“In spite of this, the relative contribution of PA in providing fatty acids for the synthesis of acyl-CoA, supplying cytosolic acyl-CoA pool seems to be much higher than the contribution of PE.”

“Kinetic analysis of the interaction between PAB-TP and the membranes containing 10 … a low dissociation constant of KD = 38 ± 5 nM. Coexistence of cholesterol or PE … PA in the membrane enhanced the PAB-TP binding to PA by … by changing the microenvironment of PA molecules in the membrane.”