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Discover Supplement-Drug Interactions

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Last Updated: 7 months ago

Possible Interaction: Phosphatidic Acid and Lisofylline

Research Papers that Mention the Interaction

Experimental studies and several clinical trials showed that LSF inhibited the generation of phosphatidic acid and free fatty acids.
Biochemical pharmacology  •  2005  |  View Paper
Furthermore, although lisofylline inhibited IL-8-stimulated neutrophil production of phosphatidic acid in vitro, it did not prevent IL-8-stimulated neutrophil adherence, chemotaxis, or intracellular calcium mobilization or N-formyl-Met-Leu-Phe (fMLP)-stimulated oxidant production in vitro.
The American journal of physiology  •  1997  |  View Paper
LSF has a marked protective effect in a variety of acute inflammatory animal models that may be due to inhibition of this shared second messenger pathway involving PA.
Lisofylline [(R)-1-(5-hydroxyhexyl)-3,7-dimethylxanthine; LSF] selectively inhibits generation of selected species of PA in P388 cells induced by TNF alpha, IL-1 beta or LPS.
Circulatory shock  •  1994  |  View Paper
Furthermore, although lisofylline inhibited IL-8-stimulated neutrophil production of phosphatidic acid in vitro, it did not prevent IL-8-stimulated neutrophil adherence, chemotaxis, or intracellular calcium mobilization or N-formyl-Met-Leu-Phe (fMLP)-stimulated oxidant production in vitro.
American journal of physiology. Lung cellular and molecular physiology  •  1997  |  View Paper