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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Phosphatidic Acid
drug:
Docetaxel
Research Papers that Mention the Interaction
“Our data showed that ERK1/2 activation depended on PKC activation since: … (a pan-PKC inhibitor) blocked docetaxel-induced ERK1/2 phosphorylation ii) docetaxel increased PKC … 30% and phosphatidic acid level by 1.6-fold iii) inhibition of PKCε and … by siRNA resulted in reduced phosphorylated ERK1/2 levels.”
Long chain n-3 polyunsaturated fatty acids increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt and PKCε/δ-induced ERK pathways.“Metabolic labeling studies showed that docetaxel (10 nM) induced two waves of PA production (130-140%), which were detected at 1 and 10 min.”
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