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Last Updated: 2 years ago

Possible Interaction: Phosphatidic Acid and Calcium Supplement

Research Papers that Mention the Interaction

There is increasing evidence that phosphatidic acid acts as an intracellular signalling molecule regulating release of calcium from intracellular stores, sphingosine kinase and protein kinase C activation and membrane budding.
Seminars in immunology  •  2002  |  View Paper
Concomitantly, a loss of acidic phosphate groups due to a formation of phosphate groups with bound calcium is observed.
The International journal of artificial organs  •  2005  |  View Paper
Conversely, a first exposure to PA only partially inhibited the CD3- or ionomycin-induced internal release of calcium , suggesting either a rapid restoration of the PA-sensitive stores, or a contribution of other mediators, such as IP3, in the CD3 activation pathway.
Immunology  •  1991  |  View Paper
Phosphatidic acid , however, did cause an elevation in intracellular calcium and is consistent with its putative role as an ionophore in other non-excitable exocrine tissues.
Experimental eye research  •  1989  |  View Paper
Calcium produced significant decrements in 32P incorporation into phosphatidylinositol, di- and triphosphatidylinositol and an increase into phosphatidic acid.
It is possible that calcium , PTH or both affects phospholipid turnover of RBC and results in production of ionophoric compounds such as phosphatidic acid which in turn allows calcium movement.
Mineral and electrolyte metabolism  •  1985  |  View Paper
Phosphatidic acid at a molar ratio of 20 mole percent produces a marked decrease in Km for phospholipid and for calcium (Km ∼ 20 μM).
Thrombosis research  •  1981  |  View Paper
Thus, the specific activity of the 32P‐phosphatidic acid increased four‐ to five‐fold in response to calcium.
Annals of neurology  •  1981  |  View Paper
Among the phospholipids tested, cardiolipin and phosphatidic acid exerted a significant increase of calcium uptake by platelets.
Thrombosis and haemostasis  •  1979  |  View Paper
At 10--60 micrograms/ml phosphatidic acid caused a concentration dependent release of calcium from the membrane fraction.
Prostaglandins and medicine  •  1978  |  View Paper
PtdA has been variously reported to activate the inositol lipid cascade, alter membrane permeability to calcium and to release calcium from intracellular stores (1,2).
Biochemical Society transactions  •  1993  |  View Paper
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