Possible Interaction: Phosphatidic Acid and Adrenocorticotropic Hormone

“Our results indicate that ACTH rapidly increases DAG, at least partly by stimulating the de novo synthesis of PA.”

“ ACTH stimulated the labeling of TPI and inhibited that of PA in a dose‐dependent manner, with maximal effect observed at 50–100 μ of the peptide.”

“ Corticotropin dose-dependently increased the formation of phosphatidylinositol bisphosphate and inhibited the production of phosphatidic acid (470% and 50% respectively of control incubations, at 100 microM of the peptide) and had no effect on phosphatidylinositol phosphate.”

“In the absence of cycloheximide, ACTH treatment elicited sustained increases in steroidogenesis (approximately 3- to 5-fold) and adrenal concentrations (approximately 2-fold) of phosphatidic acid , phosphatidylinositol, and polyphosphoinositides.”

“Lipolytic agents such as corticotropin , dibutyryl cyclic AMP, adrenaline in the presence of phentolamine and isoproterenol decreased [(32)P]P(i) incorporation into phosphatidylinositol, phosphatidylethanolamine and phosphatidic acid.”

“Although a potently steroidogenic concentration of corticotropin failed to enhance release of label from any particular phospholipid, analysis of specific activity showed that corticotropin stimulation was accompanied by an increased turnover of phosphatidylinositol and phosphatidic acid.”