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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Phenytoin also increases the metabolism of vitamin K and reduces the concentration of vitamin K-dependent proteins that are important for normal Ca++ metabolism [3].”
Osteomalacia and Phenytoin Therapy“Conversely, when bone loss was prevented by the combined administration of phenytoin and menatetrenone , serum and bone levels of menatetrenone and MK-6 increased to the levels of vehicle-treated rats.”
“When the serum and bone levels of menatetrenone and MK-6 decreased due to phenytoin administration, we observed bone loss in rats.”
Effects of menatetrenone on the bone and serum levels of vitamin K2 (menaquinone derivatives) in osteopenia induced by phenytoin in growing rats.“Combined administration of menatetrenone (30 mg/kg in diet per day) with phenytoin for 5 weeks prevented the reduction of BMD, and the level of osteocalcin was slightly increased.”
“In this study, we investigated 1) whether the administration of phenytoin induced bone loss; and 2) whether menatetrenone could prevent bone loss induced by phenytoin.”
“Thus, it is suggested that long-termed phenytoin exposure may inhibit bone formation concomitantly with insufficient vitamin K , which, at least in part, contributed to bone loss in rats.”
“ Phenytoin is known to deplete vital nutrients such as calcium, folic acid, vitamin D, vitamin K , biotin, carnitine, copper, selenium and zinc.”
INFLUENCE OF SPIRULINA ON THE PHENYTOIN INDUCED HAEMATOLOGICAL CHANGES
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