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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenytoin
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“However, the use of phenytoin as a competing agent indicated that this drug had additional negative allosteric interactions on the binding of these metabolites to HSA.”
Studies by biointeraction chromatography of binding by phenytoin metabolites to human serum albumin.“It was found that phenytoin can interact with HSA at the warfarin-azapropazone, indole-benzodiazepine, tamoxifen, and digitoxin sites of this protein.”
“It seems that the binding of the acidic drugs warfarin and phenytoin to HSA is more sensitive to the structures of the gases than for the basic drug diazepam which was previously shown to be equally affected by both gases.”
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