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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Phenytoin and Serum Albumin, Human

Research Papers that Mention the Interaction

However, the use of phenytoin as a competing agent indicated that this drug had additional negative allosteric interactions on the binding of these metabolites to HSA.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences  •  2006  |  View Paper
It was found that phenytoin can interact with HSA at the warfarin-azapropazone, indole-benzodiazepine, tamoxifen, and digitoxin sites of this protein.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences  •  2004  |  View Paper
It seems that the binding of the acidic drugs warfarin and phenytoin to HSA is more sensitive to the structures of the gases than for the basic drug diazepam which was previously shown to be equally affected by both gases.
Biochemical pharmacology  •  1986  |  View Paper