Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Phenytoin and Quinidine



Research Papers that Mention the Interaction

It significantly increases the plasma concentrations of digoxin, warfarin, many Class I antiarrhythmic drugs quinidine , procainamide, aprindine and flecainide) and Phenytoin , in some instances resulting in overt signs of clinical toxicity, including adverse cardiovascular, cardiac and central nervous system effects.
Clinical pharmacokinetics  •  1989  |  View Paper
Drug-disposition studies of orally administered quinidine in four normal healthy volunteers indicated that phenobarbital and phenytoin reduced the half-life of quinidine by approximately 50 per cent (control, 3.0 to 6.1 hours, and with anticonvulsants, 1.6 to 2.6 hours).
The New England journal of medicine  •  1976  |  View Paper
The data suggest DPH differs from other antiarrhythmic drugs such as quinidine and procaine amide.
Circulation  •  1973  |  View Paper
Phenytoin increased the use-dependent blocking effects on $$\dot V_{\max }$$ of quinidine by slowing the time course of the slow component of reactivation of $$\dot V_{\max }$$ induced by quinidine.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
with quinidine (40 mg/kg), procainamide (40 mg/kg), phenytoin (40 mg/kg), clofilium (5 mg/kg), verapamil (10 mg/kg), or propranolol (10 mg/kg) reduced the incidence of isoproterenol-induced ventricular fibrillation and death; bretylium (10 mg/kg) and nicotinic acid (100 mg/kg) had no effect.
Research communications in chemical pathology and pharmacology  •  1986  |  View Paper
The possible contributions of these effects were studied indirectly by coadministering quinidine with several compounds (d-propranolol, l-propranolol, d-practolol, practolol, pronethalol, and phenytoin ) which have varying effects on these parameters.
Archives internationales de pharmacodynamie et de therapie  •  1984  |  View Paper