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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenytoin
supplement:
Progesterone
Research Papers that Mention the Interaction
“Omission of Ca++ in the medium, or addition of a Ca++ channel blocker (D-600, 10(-4) M), of a calmodulin inhibitor (trifluoperazine, 30 microM) or of a calmodulin-dependent tubulin kinase inhibitor phenytoin , 50 microM), antagonized the stimulatory effect of progesterone.”
Progesterone-induced LHRH release in vitro is an estrogen--as well as Ca++- and calmodulin-dependent secretory process.“Enzyme inducing AEDs such as phenobarbitone, phenytoin , carbamazepine, and oxcarbazepine increase the metabolism of orally administered estrogen (and progesterone to a lesser extent).”
Controversies in contraception for women with epilepsy
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