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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Important risk factors for cardiac events were unstable potassium , (congenital) cardiac dysfunction and concurrent phenytoin use.”
Lidocaine-Associated Cardiac Events in Newborns with Seizures: Incidence, Symptoms and Contributing Factors“Liver slices (200 microm) were prepared from second trimester prenatal livers and cultured in the presence of 0, 250 microM, and 1000 microM phenytoin for 18 h. Exposure to 1000 microM phenytoin elicited 41% and 34% reductions in slice intracellular potassium and reduced glutathione (GSH) concentrations, respectively.”
“Drug therapy including cyclosporin A, enalapril, atenolol, phenytoin , necessary to control active disease and severe hypertension contributed to elevated potassium levels.”
“This effect of potassium may be important to the therapeutic effect of DPH because during epileptiform activity the extracellular K+ increases several fold.”
Frequency-dependent action of phenytoin on lamprey spinal axons“The data indicate that DPH reduced the voltage sensitive potassium conductance rather than the 'A' current or the calcium activated potassium conductance.”
“In additional dog studies, pretreatment with phenytoin decreased the rate of potassium accumulation in cisteraal cerebrospinai fluid following 20 minutes of anoxia.”
“ Phenytoin caused a moderate but consistent depression of the stimulus‐evoked responses of potassium activity , electric potential, and oxidative enzymes, consistent with diminished outflow of potassium from cells, owing either to lesser activation of cells or to a lesser exchange of ions.”
“ DPH controls the epileptogenic state by stimulating potassium uptake within synaptic terminals.”
“ DPH enhances synaptic potassium uptake by stimulating the (Naplus-Kplus) pump and a second potassium uptake process which is insensitive to ouabain.”
“These results strongly suggest that DPH controls the epileptogenic state by stimulating potassium uptake within synaptic terminals.”
“When in vivo DPH suppressed seizure discharges, it stimulated in vitro potassium uptake within synaptosomes incubated in a high-Kplus (10 mM) media.”
“ DPH … potassium uptake within synaptosomes under two situations: (a) at high sodium (50-100 mM) and low potassium (less than 2 mM) concentrations; (b) when synaptosomes … both situations, K was leaking out of synaptic terminals and the enhancement in net K uptake roughly corresponded to the ouabain inhibitable segment.”
“ Diphenylhydantoin and propranolol decreased the potassium content of the intracellular compartments.”
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