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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“ DPH counteracts the arrhythmic action of digitalis.”
Diphenylhydantoin: pharmacological and clinical use.“Both diphenylhydantoin sodium and procaine amide can suppress digitalis arrhythmias due to enhanced automaticity, but procaine amide may promote “re-entry” arrhythmias by potentiating the intraventricular conduction defect caused by the glycoside.”
“In addition, diphenylhydantoin sodium appears to antagonize the action of digitalis on the A-V node, while procaine amide increases the digitalis-induced A-V block.”
“Similar concentrations of phenytoin (1.2 × 10−5m) and quinidine (1.6 × 10−6m) reduced or abolished oscillatory afterpotentials and aftercontractions induced by digitalis in false tendons.”
Effects of phenytoin and quinidine on digitalis-induced oscillatory afterpotentials, aftercontractions, and inotropy in canine ventricular tissues.“In the presence of toxic effects of digitalis, DPH reversed the K loss and the contracture, but the loss of developed tension was not reversed by DPH.”
“Transmembrane resting potentials and action potential duration were reduced by digitalis and were returned to or above control levels in the presence of DPH.”
“ Diphenylhydantoin sodium (Dilantin) given prophylactically increased the dose of digitalis necessary to produce toxicity by 72 to 224%.”
“Second, pretreatment with diphenylhydantoin sodium significantly widened the “toxic-therapeutic” ratio of digitalis.”
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