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Last Updated: 3 years ago

Possible Interaction: Phenytoin and Digitalis

supplement:

Digitalis

Research Papers that Mention the Interaction

DPH counteracts the arrhythmic action of digitalis.
Progress in cardiovascular diseases  •  1969  |  View Paper
Both diphenylhydantoin sodium and procaine amide can suppress digitalis arrhythmias due to enhanced automaticity, but procaine amide may promote “re-entry” arrhythmias by potentiating the intraventricular conduction defect caused by the glycoside.
In addition, diphenylhydantoin sodium appears to antagonize the action of digitalis on the A-V node, while procaine amide increases the digitalis-induced A-V block.
Circulation  •  1967  |  View Paper
Similar concentrations of phenytoin (1.2 × 10−5m) and quinidine (1.6 × 10−6m) reduced or abolished oscillatory afterpotentials and aftercontractions induced by digitalis in false tendons.
Journal of molecular and cellular cardiology  •  1982  |  View Paper
In the presence of toxic effects of digitalis, DPH reversed the K loss and the contracture, but the loss of developed tension was not reversed by DPH.
Transmembrane resting potentials and action potential duration were reduced by digitalis and were returned to or above control levels in the presence of DPH.
The American journal of physiology  •  1976  |  View Paper
Diphenylhydantoin sodium (Dilantin) given prophylactically increased the dose of digitalis necessary to produce toxicity by 72 to 224%.
Second, pretreatment with diphenylhydantoin sodium significantly widened the “toxic-therapeutic” ratio of digitalis.
Circulation  •  1967  |  View Paper