Possible Interaction: Phenytoin and Calcium Supplement

“The result suggested that phenytoin and other prototype anticonvulsants significantly modulate the depolarization-induced [ Ca 2 + ] i transient of astrocytes through one or more of these VSCCs.”

“Preincubation of the human osteoblastic osteosarcoma) cell line, SaOS‐2, and normal rat osteoblastic cells with DPH decreased basal calcium uptake.”

“The opposing actions of diphenylhydantoin DPH ) and calcium on the level of [32P]phosphate incorporation into particular rat and human brain proteins have been demonstrated in this study by employing the techniques of acrylamide gel electrophoresis and autoradiography.”

“ Ca++ and phospholipid binding may be important factors in the stabilizing action of phenytoin.”

“Long-term phenytoin therapy is known to cause disturbance in calcium and bone homeostasis.”

“CBZ, PHT , and VPA, but not lamotrigine (LTG), are associated with lower levels of calcium.”

“Both phenytoin and isradipine have been shown to bind to calcium channels and to inhibit calcium entry into the cells.”

“An increase in susceptibility of neuroblastoma cells to calcium was inhibited when the cells were treated with hypothermia, diphenylhydantoin , chlorpromazine or pentobarbital; all of these treatments affect membrane permeability to calcium or membrane-associated cell metabolism.”

“ Diphenylhydantoin and chlorpromazine were found to have positive effects only when they were administered before the addition of calcium.”

“… calcium level assessed … using phenytoin compared to the control groups (control bovine pericardium group X=0.254±0.280 µg/mg; study bovine pericardium group X=0.… X=0.640±0.226 µg/mg; study porcine aortic leaflets group X=0.056±0.021 µg/mg; P<0.05).”

“ Diphenylhydantoin (DPH) (10−5 M) inhibited the spontaneous as well as the acetylcholine (10−4 M)-induced release of CA.”

“It is suggested that DPH and low ouabain concentrations inhibit CA release from the adrenal by activation of the sodium pump.”