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Last Updated: 2 years ago

Possible Interaction: Phenytoin and Calcium Supplement

Research Papers that Mention the Interaction

The result suggested that phenytoin and other prototype anticonvulsants significantly modulate the depolarization-induced [ Ca 2 + ] i transient of astrocytes through one or more of these VSCCs.
Progress in brain research  •  1992  |  View Paper
Preincubation of the human osteoblastic osteosarcoma) cell line, SaOS‐2, and normal rat osteoblastic cells with DPH decreased basal calcium uptake.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research  •  1988  |  View Paper
The opposing actions of diphenylhydantoin DPH ) and calcium on the level of [32P]phosphate incorporation into particular rat and human brain proteins have been demonstrated in this study by employing the techniques of acrylamide gel electrophoresis and autoradiography.
Brain Research  •  1977  |  View Paper
Ca++ and phospholipid binding may be important factors in the stabilizing action of phenytoin.
Neurology  •  1977  |  View Paper
Long-term phenytoin therapy is known to cause disturbance in calcium and bone homeostasis.
BMJ Case Reports  •  2012  |  View Paper
CBZ, PHT , and VPA, but not lamotrigine (LTG), are associated with lower levels of calcium.
Epilepsia  •  2003  |  View Paper
Both phenytoin and isradipine have been shown to bind to calcium channels and to inhibit calcium entry into the cells.
The Annals of pharmacotherapy  •  2002  |  View Paper
An increase in susceptibility of neuroblastoma cells to calcium was inhibited when the cells were treated with hypothermia, diphenylhydantoin , chlorpromazine or pentobarbital; all of these treatments affect membrane permeability to calcium or membrane-associated cell metabolism.
Diphenylhydantoin and chlorpromazine were found to have positive effects only when they were administered before the addition of calcium.
Neuroscience Letters  •  1987  |  View Paper
calcium level assessed … using phenytoin compared to the control groups (control bovine pericardium group X=0.254±0.280 µg/mg; study bovine pericardium group X=0.… X=0.640±0.226 µg/mg; study porcine aortic leaflets group X=0.056±0.021 µg/mg; P<0.05).
Brazilian journal of cardiovascular surgery  •  2021  |  View Paper
Diphenylhydantoin (DPH) (10−5 M) inhibited the spontaneous as well as the acetylcholine (10−4 M)-induced release of CA.
It is suggested that DPH and low ouabain concentrations inhibit CA release from the adrenal by activation of the sodium pump.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
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