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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Phenylpropanolamine and Yohimbine

Research Papers that Mention the Interaction

Tyramine containing foods (red wine, liver, cheese) and nasal decongestants or diet aids containing phenylpropanolamine should be strictly avoided when yohimbine is used, to prevent a hypertensive crisis.
Swiss medical weekly  •  2003  |  View Paper
Prazosin (2 mg/kg, SC) pretreatment did not significantly affect the potentiation of opioid antinociception by ephedrine and PPA , while yohimbine (4 mg/kg, SC) effectively antagonised this enhancing effect.
Psychopharmacology  •  2005  |  View Paper
Yohimbine (5 mg/kg, ip), a selective alpha 2-adrenoreceptor antagonist, completely blocked the potentiating effect of phenylpropanolamine on carbon tetrachloride hepatotoxicity, providing further evidence that the increased hepatotoxic response with phenylpropanolamine cotreatment was mediated through alpha 2-adrenoreceptor stimulation.
Toxicology and applied pharmacology  •  1991  |  View Paper