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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenylephrine
supplement:
Yohimbine
Research Papers that Mention the Interaction
“The maximal relaxation induced by yohimbine in the human corpus cavernosum strips pre-contracted with phenylephrine was 100±0% and only 30.5±5.0% when they were pre-contracted with 60-mM potassium (K+) solution.”
Yohimbine relaxes the human corpus cavernosum through a non-adrenergic mechanism involving the activation of K+ATP-dependent channels“ Yohimbine was titrated up to 10.8 mg po tid in an unsuccessful effort to wean the patient from phenylephrine.”
“Both the alpha 1-selective agonist phenylephrine in the presence of yohimbine (0.3 microM, alpha 2-selective antagonist) and the alpha 2-selective agonist B-HT 933 in the presence of prazosin (0.3 microM, alpha 1-selective antagonist) evoked strong vasoconstriction.”
“4 The competitive and surmountable nature of the antagonism of phenylephrine‐induced contractions by prazosin and yohimbine allowed calculation of antagonist dissociation constants.”
“Both the alpha 1-selective agonist phenylephrine in the presence of 0.3 microM yohimbine and the alpha 2-selective agonist B-HT 933 in the presence of 0.3 microM prazosin elicited prominent and concentration-dependent contractions.”
“Prazosin and yohimbine produced a parallel rightward shift in the control curve for phenylephrine and clonidine, respectively.”
“ Yohimbine induced a 3.1-fold (+/- 0.5) shift in the dose of epinephrine, which raised blood pressure 25 mm Hg, and only a 1.9-fold (+/- 0.2) shift in the response to phenylephrine (p less than 0.01).”
“ Yohimbine potently, but not selectively, antagonized postsynaptic responses to noradrenaline and phenylephrine in both arteries and veins, and enhanced stimulation-induced transmitter release to a greater extent in arteries than in veins.”
“However, the antagonist properties of rauwolscine and yohimbine (non-subtype selective alpha(2)-adrenoceptor antagonists) against phenylephrine showed that this agonist also activates alpha(2)-adrenoceptors in pulmonary veins.”
Phenylephrine contracts porcine pulmonary veins via alpha(1B)-, alpha(1D)-, and alpha(2)-adrenoceptors.“Phentolamine (3.55 x 10(-5) M), prazosin (2.38 x 10(-5) M) and yohimbine (2.821 x 10(-5) M) significantly inhibited the aggregatory responses of the fish melanophores to adrenaline, nor-adrenaline, clonidine and phenylepherine.”
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