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“Crocin and vitamin E attenuated lipid peroxidation, improved the reduction of contractile responses by KCl and PE and restored the decrease in ACh relaxation in rat aorta.”
“Differential reactivity responses to PE may have been the result of protective effects of Arg, VE , and VC, implicating oxidative stress in endothelial dysfunction as well as in the upregulation of smooth muscle contractility.”
“ Vitamin E significantly improved the impaired endothelium-dependent relaxations, further it decreased the enhanced contractile response to phenylephrine and 5-hydroxytryptamine in diabetic rings.”
“Despite this ameliorating effect, vitamin E treatment caused an increase in contractile response to PE and a decrease in the relaxant response to Ach and SNP in arthritic rats.”