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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenylephrine
supplement:
Taurine
Research Papers that Mention the Interaction
“Preincubation with taurine 20-60 mM did not affect the basal tone but inhibited the contraction induced by phenylephrine , and the inhibitory effect was attenuated by TEA in isolated renal and mesenteric arterial rings.”
Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries.“ Phenylephrine had no effect on osmolyte release from isolated KC and SEC, but increased taurine (but not inositol) release from PC and inositol (but not taurine) efflux from HSC.”
“In sham-operated rats, intravenous infusion of phenylephrine increased blood pressure and the hypothalamic release of GABA and taurine.”
“In the range 0.5-20 mM, taurine concentration-dependently reduced the phenylephrine-induced intracellular calcium increase in cell suspensions and 20 mM taurine decreased the effect of 10(-5) M phenylephrine (measured in the presence of 10(-6) M propranolol) by about 80%.”
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