Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Phenylephrine and Tangeretin

supplement:

Tangeretin

Research Papers that Mention the Interaction

In human cavernosum treated with thapsigargin (inhibitor of …+)-ATPase) in Ca(2+)-free medium, PMF suppressed the concentration-… human cavernosum to phenylephrine and a further suppression was found when SKF-96365 (a blocker of store-operated … and Y-27632 (inhibitor of Rho-kinase)), but not nifedipine, were added sequentially.
In normal Krebs solution with nifedipine (blocker of l-type Ca(2+) channels), or in Ca(2+)-free Krebs solution, PMF caused a further inhibition of human cavernosum contracted with phenylephrine.
PMF caused … of phenylephrine precontracted human cavernosal strips, and this effect was slightly inhibited by N(G)-nitro-l-arginine, a nitric oxide synthase inhibitor, but not by ODQ (soluble guanylate cyclase inhibitor), TEA (tetraethylammonium, blocker of voltage-dependent K(+) channels) or glybenclamide (blocker of ATP-dependent K(+) channels).
European journal of pharmacology  •  2012  |  View Paper
Thoracic aortic and mesenteric rings of PMF treated rats produced lower maximal contraction to phenylephrine that was normalized by NG-nitro-L-arginine (L-NA) or endothelial removal.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2016  |  View Paper