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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenylephrine
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“Pilot experiments showed that the vasoconstrictor effect of S1P was enhanced markedly in the presence of phenylephrine (PE).”
Sphingosine-1-Phosphate Enhances α1-Adrenergic Vasoconstriction via S1P2–G12/13–ROCK Mediated Signaling“Furthermore, in cultured H9c2 cells exposed to phenylephrine, S1P was revealed to decrease cardiomyocyte size and the exaggerated expression of fetal cardiac genes.”
“Ex vivo inhibition of sphingosine-1-phosphate (S1P) synthesis significantly reduced vasoconstriction in response to KCl, phenylephrine or prostaglandin F2&agr; (PGF2&agr;) in intact and endothelium-denuded aortic rings.”
[OP.7C.06] VASCULAR TRANSCRIPTOME PROFILING IDENTIFIES SPHINGOSINE KINASE 1 AS A KEY MODULATOR OF ANGIOTENSIN II-INDUCED HYPERTENSION
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