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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Phenylephrine
supplement:
Resveratrol
Research Papers that Mention the Interaction
“Phenylephrine-induced cremaster arteriolar constriction was impaired, whereas RSV treatment significantly mitigated the vessel responsiveness to phenylephrine.”
Resveratrol Mitigates High-Fat Diet–Induced Vascular Dysfunction by Activating the Akt/eNOS/NO and Sirt1/ER Pathway“Curcumin, zingerone, resveratrol , guaiacol, pterostilbene and isoeugenol significantly inhibited phenylephrine disappearance, while vanillin, propylparaben and eugenol did not.”
“In cultured cardiomyocytes, cardiomyocyte hypertrophy induced by the α1-agonist phenylephrine was inhibited by the overexpression of SIRT1 as well as resveratrol , both of which down-regulated p300 protein levels but not p300 mRNA levels.”
Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein*“ RVT (10−6–10−4 M) produced concentration-dependent relaxation responses in rat corpus cavernosum precontracted by phenylephrine.”
“Both the activation of Sirt1 with resveratrol RSV ) and overexpression of Sirt1 inhibited phenylephrine (PE)-induced NCM hypertrophy and prevented PE-induced down-regulation of fatty acid oxidation genes.”
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