Possible Interaction: Phenylephrine and Potassium

“After potassium chloride alone, the potassium level rose to 0.64 +/- 0.03 mmol (mean +/- S.E.M.); phenylephrine augmented the rise (0.93 +/- 0.09 mmol, P less than 0.025) and prolonged it, without changing urinary potassium excretion.”

“The α agonists clonidine and phenylephrine both inhibited the potassium currents and elevated intracellular calcium levels.”

“The resting tissue tension increased as the potassium concentration was increased from 4.7 mM to 20 mM or 30 mM. The maximum contraction induced by 200 μM phenylephrine was significantly decreased in the presence of 30 mM potassium compared with 4.7 mM potassium.”

“Compared with KCl alone, the alpha-agonist phenylephrine caused more than a 25% increment in the peak plasma potassium, and reduced the volume of distribution of the potassium load.”

“Carbachol and phenylephrine elicited a biphasic increase in potassium release (86Rb release) that was dose related and could be blocked by atropin and phentolamine, respectively.”

“ Phenylephrine caused release of potassium from the liver; this effect was blocked by phentolamine, but not by propranolol.”