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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenylephrine
supplement:
Phosphatidylinositol 4,5-Diphosphate
Research Papers that Mention the Interaction
“ Phenylephrine stimulated the rate of hydrolysis of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate by 63% in these cells.”
Alpha 1-adrenoceptors in the corneal endothelium.“Under dialysis with GTP-γ-S, inhibiting phospholipase C by edelfosine or intracellularly adding exogenous phosphatidylinositol-4,5-bisphosphate PIP2 ) decreased run-down, whereas extracellularly applying carbachol and phenylephrine accelerated it.”
Inhibition of the Magnesium-Sensitive TRPM7-like Channel in Cardiac Myocytes by Nonhydrolysable GTP Analogs: Involvement of Phosphoinositide Metabolism“Addition of the alpha1-adrenergic receptor agonist phenylephrine (50 microM) caused reductions in PIP2 , but only in caveolae.”
“Under these conditions, phenylephrine caused radioactivity in phosphatidylinositol, PtdIns-4-P and PtdIns-4,5-P2 to fall by more than 50% within 30 s and to remain at the depressed value for the duration of the incubation (10 min).”
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