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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenylephrine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“By confocal …, phenylephrine (stimulating both alpha(1A)- and alpha(1B)-adrenoceptors) or … (alpha(1A)-selective agonist) induced an increase in intracellular calcium by 2.33 +/- 0.18-fold and 1.81 +/- 0.43-fold, respectively, while 5-methylurapidil (alpha(1A)-selective antagonist) partly blocked calcium mobility stimulated by phenylephrine.”
Functional alpha(1)-adrenoceptor subtypes in human submandibular glands.“When administered concurrently with Ca, phenylephrine at 150, 300, and 450 ng/kg.min increased MAP by 6%, 7%, and 13%, respectively.”
“In 7 day callus, PE (10−6 M) significantly induced an increase in force that was greater than passive force generated in calcium‐free KH (n = 8, mean 51% increase, 95% CI: 26–76%).”
α1 adrenergic receptor agonist, phenylephrine, actively contracts early rat rib fracture callus ex vivo“In the presence of extracellular Ca2+ (2.5 mmol l−1), Nef (0.1, 1 and 10 μmol l−1) inhibited [Ca2+]i elevation induced by high K+ and phenylephrine ( PE ) in a concentration‐dependent manner (P < 0.05).”
“Increasing calcium and cross-bridge cycling with 10 microM phenylephrine for 48 h resulted in a threefold increase in Clock and a translocation of the protein to the nucleus.”
“ phenylephrine induced contraction in calcium free media , suggesting that its site of action is in the intracellular space.”
“We showed that potassium and phenylephrine , which increase the cytosolic -free calcium concentration of the smooth-muscle cells, also indirectly influence the calcium concentration in the endothelial cells.”
“ L-type Ca2+ channel blocker, markedly reduced the contractions induced by bath applied phenylephrine (alpha 1-agonist, 100 microM) but only partially blocked the contractions produced by bath applied ATP (500 microM).”
“Published data indicate that 1-3 microM adrenomimetic phenylephrine increases the concentration of calcium ions in the cytoplasm of cultured hepatocytes.”
“In calcium-free medium PE induced a transient rise of the intracellular calcium concentration with a depressed plateau.”
“In smooth muscle cells isolated from swine renal interlobar arteries, phenylephrine (PE) at concentrations of 1–10 µM produced biphasic increases of the intracellular calcium concentration.”
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