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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Phenylephrine
supplement:
Biochanin A
Research Papers that Mention the Interaction
“Pre-incubation with prunetin (3 and 10 μg/mL) inhibited vasoconstriction induced by the supply of Ca2+ in rat aortic rings pre-contracted with PE or KCl in a Ca2+-free Krebs–Henseleit (KH) buffer.”
Prunetin Relaxed Isolated Rat Aortic Rings by Blocking Calcium Channels“Glibenclamide (3 x 10(-6) mol/L), a selective inhibitor of ATP-sensitive potassium channels, and tetraethylammonium (5 x 10(-…) mol/L), a Ca2+ -activated K+ channel inhibitor, significantly attenuated the relaxation induced by biochanin A. The vasoconstriction induced by phenylephrine was … by biochanin A in Ca2+ -free medium.”
“Contractile responses induced by phenylephrine (PE), KCl and CaCl2 were antagonized by 10-7~10-4 mol/L biochanin A. The transient contraction elicited by PE was significantly attenuated by 10-5 mol/L biochanin A in Ca2+-free medium.”
Endothelium-independent Vasorelaxant Effect of the Phyto-oestrogen Biochanin A on Rat Thoracic Aorta
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