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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenylbutazone
supplement:
Vitamin C
Research Papers that Mention the Interaction
“ Ascorbic acid inhibits these pro-oxidant actions of phenylbutazone.”
Oxidative damage to lipids and alpha 1-antiproteinase by phenylbutazone in the presence of haem proteins: protection by ascorbic acid.“Other types of compounds, such as chloretone, aminopyrine, meprobamate and phenylbutazone , also increase the urinary excretion of ascorbic acid in rats2,3.”
“ Phenylbutazone and meclofenamic acid, but not flufenamic acid, enhanced the peroxidation, which was again inhibited by ascorbic acid.”
Promotion of oxidative damage to arachidonic acid and alpha 1-antiproteinase by anti-inflammatory drugs in the presence of the haem proteins myoglobin and cytochrome C.“ Phenylbutazone and orphenadrine in doses of 20–50 mgm./day for 4 days to adult rats produced about a 20-fold increase in L-ascorbic acid excretion.”
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