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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenylbutazone
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“It was found that the oxidation of HSA by Tau-NBr2, but not by Tau-NHCl, provoked a significant increase in the association constant with phenylbutazone.”
Oxidative Alteration of Trp-214 and Lys-199 in Human Serum Albumin Increases Binding Affinity with Phenylbutazone: A Combined Experimental and Computational Investigation“Its fluorescence in HSA solutions is strongly suppressed by phenylbutazone.”
“ Phenylbutazone is an anti-inflammatory drug, which binds to the drug-binding site I of HSA.”
“The induced ellipticities of the complexes of ibuprofen, flufenamic acid and phenyl butazone with G-HSA were diminished in comparison with those with HSA.”
“It was demonstrated that the binding of PB to HSA increased with the change in the tertiary conformation caused by hydrogen ions but decreased with that in the secondary conformation caused by a concentration change of NaSCN and urea.”
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