Possible Interaction: Phenylalanine and Valine

“Furthermore, the chlamydial growth inhibition induced by leucine, isoleucine, methionine, or phenylalanine was completely reversed by concomitant addition of valine.”

“Substitution of a valine for a phenylalanine destabilizes the JH2 domain of JAK2 causes loss of the auto‐inhibitory activity of this domain and explains some of the biological phenomena observed in patients with myeloproliferative disorders (MPD).”

“Since large neutral amino acids share the same high affinity blood-brain barrier transport system, entry of phenylalanine into the brain will be diminished by the simultaneous presence of high serum concentrations of valine ; the pituitary, lying outside the blood-brain barrier, is not subject to these competitive effects.”

“ Valine significantly blunted the PRL response to phenylalanine , supporting an effect of phenylalanine within the blood-brain barrier to stimulate PRL release.”

“Administration of certain large neutral amino‐acids valine , isoleucine, leucine–VIL) appears to reduce phenylalanine concentrations in the cerebrospinal fluid of humans and in the brain of rats.”

“Abstract Nitrogen balance rapidly became negative when either or both phenylalanine and valine were withdrawn from the diet of five healthy individuals and four patients with chronic renal failure.”

“Feeding diets containing additional methionine and phenylalanine to protein-depleted rats caused a fall in concentration of the group of amino acids (leucine, isoleucine, valine and histidine) limiting growth.”

“Substitutions … two conserved phenylalanines (F522 and …) by valines in the MC motif strongly impaired the function of BmAgo1 in translation repression and its localization in P‐bodies, suggesting that these two amino acid residues in the MC motif of BmAgo1 are prerequisites for mRNA translation repression in B. mori.”

“Substitution of phenylalanine for valine increased, and substitution of lysine or glycine for valine considerably decreased the rate of phosphorylation.”

“—High circulating levels of phenylalanine caused depletions of threonine, valine , methionine, isoleucine, leucine, histidine, tryptophan, and tyrosine in immature and adult rat brains.”

“Among free amino acids in muscle, L-glutamic acid, L-alanine, L-valine , L-leucine and L-phenylalanine were significantly (p<0.05) higher in GE than in control.”