Possible Interaction: Phenylalanine and Tyrosine

“The ratio of phenylalanine to tyrosine was increased with 11.7% (95% CI: 1.0 to 23.5) during 6 months.”

“Integration of net tyrosine and phenylalanine uptake over the entire infusion period predicted a 10% difference in skeletal muscle protein mass between treated and control hindlimbs.”

“Mutation of these sites to phenylalanine results in significantly decreased Fyn‐dependent PlxnA tyrosine phosphorylation.”

“Using cultured mouse brain-derived cells and an antibody specific to Phe-tubulin, we showed that: (i) Phe incorporation …) the rate of neurite retraction declines as level of C-terminal Phe incorporation increases; (vi) this inhibitory effect of Phe … tyrosine ; (vii) microtubule dynamics is reduced … is expressed (plasmid transfection).”

“In conclusion, healthy children are capable of converting phenylalanine to tyrosine, but the need for tyrosine cannot be met by providing extra phenylalanine.”

“Substitution of this tyrosine with phenylalanine prevented the matrix metalloproteinase 2-dependent degradation of MLC2.”

“Substitution of either tyrosine with phenylalanine led to a substantial reduction in the overall tyrosine phosphorylation level of TRPV4, suggesting that these two tyrosines constitute major phosphorylation sites.”

“Substitution of tyrosine with phenylalanine (Y459F) in FcγRIIB‐BGPa completely abrogated its ability to inhibit calcium influx, indicating that the motif surrounding Y459 is ITIM.”

“The substitutions of Phenylalanine8 by a tyrosine , phenylglycine or homophenylalanine were deleterious for high affinity.”

“Substitution of all three tyrosines with phenylalanines markedly reduced sulfation and prevented binding to P-selectin.”