Possible Interaction: Phenylalanine and Trypsin

“Our data indicate that active trypsin in duodenum is responsible for the inhibition of L-phenylalanine stimulated pancreatic enzyme secretion in man.”

“ Phenylalanine increased the concentrations of plasma insulin, cholecystokinin, and pancreatic DNA (mg/g) and the expression of trypsin gene but decreased the pancreatic protein:DNA ratio and tended to decrease the pancreas weight (g/kg of BW).”

“Conclusively, these results suggested that Phe regulates the synthesis or secretion of α-amylase, trypsin and lipase through mRNA translation initiation factors – S6K1 and 4EBP1.”

“In PTS, the Phe increased (P < 0.05) α-amylase and trypsin synthesis , secretion and mRNA expression, as well as the phosphorylation of S6K1 and 4EBP1.”

“ Phenylalanine accumulation in mucosal strips isolated from rat small intestine was significantly inhibited (P less than 0.01) after preincubation with trypsin , chymotrypsin, phospholipase D and neuraminidase.”

“Conversion of methionine 70 at the P4 site of SSI(Lys73) to glycine or alanine resulted in increased inhibitory activity toward trypsin and lysyl endopeptidase, while replacement with phenylalanine weakened the inhibitory activity toward trypsin.”

“The production of poly-phenylalanine under the direction of polyuridylic acid, the binding capacity for specific sRNA, the capacity to bind [ 14 C]polyuridylic acid (to form polysomes), are sensitive to the trypsin treatment in that order.”