Possible Interaction: Phenylalanine and Sodium Dodecyl Sulfate

“PKU adolescents (age older than 15 years, AD-SoS SDS −0.54 ± ….85 ± 1.21) and patients with poor compliance with treatment blood phenylalanine >10 mg/dL, AD-SoS SDS −0.47 ± … −0.97 ± 1.14) showed lower BTT SDS with respect to normal population (… P < 0.001, respectively).”

“When the sites in the interface is saturated, SDS interacts with VAL 73, HIS 74, ASN 147 and PHE 152, the key residues of the enzyme activity, and leads to the decrease of CAT activity.”

“At concentrations of 0.1 ppm and above, SDS decreases the uptake of thymidine, uridine and phenylalanine into the acid-soluble sponge fraction.”

“The separation and the migration order of D- and L-phenylalanine were strongly affected by adding an anion surfactant sodium dodecylsulfate ( SDS).”

“In the presence of sodium dodecyl sulfate SDS ), the CD bands of NCS originating from phenylalanyl , tyrosyl, and cystinyl residues decreased, indicating a conformational change around the chromophore (CNS-chr).”

“The disorganization of the native tertiary structure by SDS was expressed in a decrease of the circular dichroism bands related to the tyrosine and tryptophan chromophores and in appearance of the vibronic fine structure in the phenylalanine band zone.”