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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Phenylalanine
supplement:
Sapropterin
Research Papers that Mention the Interaction
“At week 26 in the sapropterin plus diet group, mean phenylalanine tolerance was 30.5 (95% confidence interval 18.7–42.3) mg/kg/day higher than in the diet-only group (p < 0.001).”
Efficacy, safety and population pharmacokinetics of sapropterin in PKU patients <4 years: results from the SPARK open-label, multicentre, randomized phase IIIb trial“The efficacy of sapropterin in reducing blood phenylalanine levels has been demonstrated in clinical studies of individuals with phenylketonuria older than 4 years of age.”
“ Sapropterin can reduce phenylalanine (Phe) levels in tetrahydrobiopterin (BH4)-responsive patients, potentially preventing the intellectual impairment caused by elevated Phe levels.”
“ Sapropterin causes reductions in blood phenylalanine concentrations in sensitive patients with phenylketonuria (PKU).”
“Tetrahydrobiopterin (BH4; sapropterin ) reduces phenylalanine (Phe) levels in responders, enabling relaxation of dietary therapy.”
“Subjects continuously exposed to sapropterin showed an average 34% decrease in blood phenylalanine (Phe)--from 591 ± 382 μmol/L at baseline to 392 ± 239 μmol/L (p = 0.0009) after 5 years.”
“Recent publications report a decrease in blood phenylalanine concentration in some patients treated with sapropterin dihydrochloride.”
“ Sapropterin enhances phenylalanine hydroxylase activity, thus lowering blood phenylalanine (Phe) concentration while increasing protein tolerance in sapropterin-responsive patients.”
“Treatment with sapropterin resulted in clinically significant and sustained reductions in blood Phe concentrations and increased dietary Phe tolerance in well-designed clinical studies in PKU patients who responded to BH4.”
“Balancing the need for maintained control of blood phenylalanine with diet relaxation is complex when administering sapropterin.”
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