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Last Updated: a year ago

Possible Interaction: Phenylalanine and Sapropterin





Research Papers that Mention the Interaction

At week 26 in the sapropterin plus diet group, mean phenylalanine tolerance was 30.5 (95% confidence interval 18.7–42.3) mg/kg/day higher than in the diet-only group (p < 0.001).
Orphanet Journal of Rare Diseases  •  2017  |  View Paper
The efficacy of sapropterin in reducing blood phenylalanine levels has been demonstrated in clinical studies of individuals with phenylketonuria older than 4 years of age.
Genetics in Medicine  •  2015  |  View Paper
Sapropterin can reduce phenylalanine (Phe) levels in tetrahydrobiopterin (BH4)-responsive patients, potentially preventing the intellectual impairment caused by elevated Phe levels.
Molecular genetics and metabolism  •  2021  |  View Paper
Sapropterin causes reductions in blood phenylalanine concentrations in sensitive patients with phenylketonuria (PKU).
Acta paediatrica  •  2017  |  View Paper
Tetrahydrobiopterin (BH4; sapropterin ) reduces phenylalanine (Phe) levels in responders, enabling relaxation of dietary therapy.
Journal of pediatric endocrinology & metabolism : JPEM  •  2016  |  View Paper
Subjects continuously exposed to sapropterin showed an average 34% decrease in blood phenylalanine (Phe)--from 591 ± 382 μmol/L at baseline to 392 ± 239 μmol/L (p = 0.0009) after 5 years.
Molecular genetics and metabolism  •  2015  |  View Paper
Recent publications report a decrease in blood phenylalanine concentration in some patients treated with sapropterin dihydrochloride.
The Cochrane database of systematic reviews  •  2015  |  View Paper
Sapropterin enhances phenylalanine hydroxylase activity, thus lowering blood phenylalanine (Phe) concentration while increasing protein tolerance in sapropterin-responsive patients.
The Turkish journal of pediatrics  •  2015  |  View Paper
Treatment with sapropterin resulted in clinically significant and sustained reductions in blood Phe concentrations and increased dietary Phe tolerance in well-designed clinical studies in PKU patients who responded to BH4.
Expert opinion on drug metabolism & toxicology  •  2013  |  View Paper
Balancing the need for maintained control of blood phenylalanine with diet relaxation is complex when administering sapropterin.
Molecular genetics and metabolism  •  2013  |  View Paper
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