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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Phenylalanine
supplement:
Sapropterin Dihydrochloride
Research Papers that Mention the Interaction
“BACKGROUND Sapropterin dihydrochloride (BH4, tetrahydrobiopterin) can lower plasma phenylalanine (Phe) concentrations for a subset of patients with phenylketonuria (PKU), an inborn error of metabolism.”
The effects of sapropterin on urinary monoamine metabolites in phenylketonuria.“Treatment with the BH4 analog sapropterin dihydrochloride (10 mg/kg/day) was initiated and evoked a 50% reduction of the plasma phenylalanine levels.”
Beneficial Effect of BH4 Treatment in a 15-Year-Old Boy with Biallelic Mutations in DNAJC12.“ Sapropterin dihydrochloride (BH4) reduces phenylalanine (Phe) levels and improves white matter integrity in a subset of individuals with phenylketonuria (PKU) known as “responders.””
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