Possible Interaction: Phenylalanine and Proline

“Three of the nine cleavage reactions occur between a phenylalanine or a tyrosine and a proline.”

“In the presence of proline , small additional increases of the EGF effect on DNA synthesis were stimulated by phenylalanine and tyrosine.”

“This effect of phenylalanine can be countered by including a high concentration of a space-filling osmolyte such as proline in the reaction mixtures.”

“Substitution of a leucine for a proline at position 281 in phenylalanine hydroxylase increases the Km for phenylalanine >20‐fold over that of the wild‐type.”

“Certain other amino acids (L-valine, L-alanine, L-methionine, L-phenylalanine , L-tryptophan and L-hydroxyproline) significantly stimulated proline uptake.”

“The … of phenylalanine was decreased by … addition of proline or arginine to the inadequate protein diet but not by the addition of threonine, methionine, lysine or a mixture of … amino acids, indicating that proline and arginine were limiting the utilization of dietary amino acids in the inadequate protein diet.”

“Piglets receiving additional proline and with symptoms of diarrhea oxidized phenylalanine at rates 50 to 70% higher than healthy piglets.”

“The MD simulation results demonstrate that the morphology of Pro affects the adsorption stability of Phe.”