Possible Interaction: Phenylalanine and Phenylacetic Acid

“Four strains were further tested and PAA formation was substantially increased by phenylalanine , 4-hydroxyPAA by tyrosine and IAA by tryptophan.”

“Changes in dietary phenylalanine (whether in absolute amount or in the proportion of phenylalanine in the diet) are significantly correlated with changes in unconjugated phenylacetic acid.”

“The production of PAA from Phe with SL was inhibited (p<0.05) by 73, 54 and 76% in B, P and BP, respectively.”

“… Phe … PAA with SL tended to be inhibited by 12, 11 and 8% in B, P and BP, respectively, during the 6 h incubation period, but …, whereas Phe production from PAA with B(6) tended to be enhanced by 13, 16 and 8% in B, P and BP, respectively.”

“Both oxidation and oxygenation of L-phenylalanine by the enzyme were also inhibited by phenylacetic acid competitively.”

“omega-Phenyl fatty acids such as phenylacetic acid , 3-phenylpropionic acid and 4-phenylbutyric acid were competitive inhibitors of the enzyme towards L-phenylalanine.”

“ L-Phenylalanine enhanced phenylacetic acid production; 5 mg L-phenylalanine per millilitre stimulated maximum production of phenylacetic acid.”

“Peptides (2-4 amino acids) containing L-phenylalanine also stimulated phenylacetic acid production as did phenylpyruvic acid.”

“The samples of tropic acid obtained, following administration of phenylalanine and phenylacetic acid , were degraded and the location of the C 14 determined.”