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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Phenylalanine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In CaR-expressing HEK-293 cells, 10 mM L-phenylalanine lowered the EC50 for Ca2+o from approx.”
Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylation.“Based on our observation, we would like to propose that phenylalanine uptake/turnover is under tight control by calcium which in turn could offer an additional novel mechanism in the aetiology of HPA.”
“The presence of Phe caused a significant increase in % Ca (52·3 (sem 6·5) % in the presence of Phe v. 31·1 (sem 8·9) % in the absence of Phe, regardless of the amount of Ca intake; paired t test, P = 0·02).”
Luminal calcium concentration controls intestinal calcium absorption by modification of intestinal alkaline phosphatase activity“A high dietary content of calcium (25.9 vs 11.8 g/kg) reduced chick performance and the digestibility of glutamic acid, leucine and phenylalanine but increased the digestibility of lysine and histidine.”
“Dramatic alterations in phenylalanine resonances are seen during the binding of the third mole of calcium , corresponding to filling the sole low affinity site.”
“ L-Phenylalanine methyl ester inhibited the activation of purified bovine prothrombin by autoprothrombin C, Ac-globulin, phospholipid, and calcium.”
“Besides Gln, other amino acids including L-phenylalanine and l-cysteine (Cys) also induced Ca2+ response, activation of Ras → ERK, and MKP-1 induction, albeit to a lesser degree.”
Glutamine up-regulates MAPK phosphatase-1 induction via activation of Ca2+→ ERK cascade pathway
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