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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Phentolamine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Our results provide evidence that phentolamine modulates the human platelet function and that its effects could also be related to a decrease of Ca++ availability.”
Influence of phentolamine on platelet aggregation, thromboxane B2 production and release reaction.“However, after cumulative CaCl2 (0.5, 1, 1.5, 2, 2.5, and 3 mmol/L), the Ca2+ -induced contraction was significantly inhibited in the osthole and phentolamine groups compared with controls (P < 0.05).”
Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats.“It suggests that the action of Phe may be related to the blockade of calcium entry.”
“ Phentolamine and the aqueous soluble alpha 1-adrenergic antagonist BE-2254 administered as late as 2 min before reperfusion similarly attenuated the increase in tissue calcium.”
“Pretreatment with the alpha-adrenergic blocking agents phentolamine or prazosin prevented the increase in total and intracellular calcium.”
“The relaxed tension caused by phentolamine was reversed by addition of Ca in a dose-dependent manner.”
“The mobilization of Ca++ from cardiac SRF by the alpha blocking agent, phentolamine , may be related to its ability to decrease the contractility of cardiac muscle.”
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