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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Phenothiazine and Thiamine

supplement:

Thiamine

Research Papers that Mention the Interaction

Co-administration of PTT with thiamine (molar ratio, 200:1) by oral route evoked severe neuro-muscular symptoms of athiaminosis in all of the animals.
These results suggest that PTT exerts its anti-thiamine effect not only by inhibiting the absorption of thiamine from the intestinal tract but also by antagonizing thiamine metabolism at the cellular level.
The Journal of vitaminology  •  1968  |  View Paper