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Last Updated: 3 years ago

Possible Interaction: Phenobarbital and Vitamin E

supplement:

Vitamin E

Research Papers that Mention the Interaction

Vitamin E may decrease the oxidative stress created by PB by also enhancing other antioxidants; therefore, we also measured hepatic glutathione S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase and NAD(P)H:quinone reductase (DT-diaphorase) activities and glutathione and ascorbic acid concentrations.
The Journal of nutrition  •  2002  |  View Paper
The objective of the present study was to investigate whether the modulatory effect of dietary alpha-tocopherol acetate on hepatic cytochrome PROD activity is influenced by the presence of phenobarbital.
These results suggest that, … the presence of phenobarbital, dietary alpha-tocopherol acetate efficiently affects tissue alpha-tocopherol levels and inhibits lipid peroxidation and that diets supplemented with 5 or 15 g/kg alpha-tocopherol acetate enhance hepatic cytochrome PROD activity compared with alpha-tocopherol acetate-deficient or -adequate diets.
Nutrition and cancer  •  1998  |  View Paper
Phenobarbital both depleted hepatic alpha-tocopherol and increased plasma alpha-tocopherol significantly.
Prostaglandins, leukotrienes, and essential fatty acids  •  1992  |  View Paper
PB decreased hepatic alpha-tocopherol significantly.
The removal of significant amounts of hepatic alpha-tocopherol during oxidative stress induced by PB might diminish endogenous inhibition of hepatic PG synthesis by a-tocopherol.
Prostaglandins, leukotrienes, and essential fatty acids  •  1991  |  View Paper
By contrast tocopherol strongly potentiated the inductive effect of phenobarbital toward UDPGT activity (group I substrates) in rats fed the peroxidized fish oil.
In rats fed a de-peroxidized oil, the inductive effect of phenobarbital on UDP-glucuronosyltransferase (UDGPT) activity was depressed by tocopherol.
The modification of the inductive effect of phenobarbital in combination with tocopherol on UDPGT activities was concomitant with an increase in seric transaminase activity and with a reverse effect as revealed from the study of the rate of fluorescent probes penetration in microsomes.
Comptes rendus des seances de la Societe de biologie et de ses filiales  •  1987  |  View Paper
alpha-Tocopherol inhibited the binding of BP to nuclear macromolecules in the presence of phenobarbital (PB)-induced microsomes.
Journal of nutritional science and vitaminology  •  1979  |  View Paper
When vitamin E was given at the same time as the phenobarbitone and (75)Se, there was a large increase in the amount of (75)Se and (75)Se(2-) found in the smooth reticulum.
The Biochemical journal  •  1973  |  View Paper