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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Phenobarbital
supplement:
Selenium
Research Papers that Mention the Interaction
“Analysis of GGT foci … 8 wk of PB feeding indicated ….0 ppm selenium caused a trend towards an increase in the number of foci/cm3 of liver and mean focal volume … significant increase in GGT focal volume as a percentage of liver volume by 8 wk of PB feeding.”
“Thus, high dietary selenium concentrations prior to PB enhance the tumor-promoting ability of PB.”
Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats.“However, selenium enhanced the stimulatory effect elicited by phenobarbital on aniline metabolism.”
“When phenobarbital and selenium were administered simultaneously, the opposing effects on the duration of pentobarbital hypnosis cancelled each other.”
“With respect of hepatic metabolism, differential effects were observed with the inhibitory effect elicited by selenium on ethylmorphine metabolism being prevented by phenobarbital.”
“It will be shown that the inductive effect of phenobarbitone on the microsomal drug-metabolizing enzyme system of normal rats is accompanied by a large increase in the uptake of selenium and its conversion to selenide; when vitamin E is withdrawn from the diet, this effect cannot be demonstrated.”
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