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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Phenobarbital and Selenium



Research Papers that Mention the Interaction

Analysis of GGT foci … 8 wk of PB feeding indicated ….0 ppm selenium caused a trend towards an increase in the number of foci/cm3 of liver and mean focal volume … significant increase in GGT focal volume as a percentage of liver volume by 8 wk of PB feeding.
Thus, high dietary selenium concentrations prior to PB enhance the tumor-promoting ability of PB.
Cancer research  •  1985  |  View Paper
However, selenium enhanced the stimulatory effect elicited by phenobarbital on aniline metabolism.
When phenobarbital and selenium were administered simultaneously, the opposing effects on the duration of pentobarbital hypnosis cancelled each other.
With respect of hepatic metabolism, differential effects were observed with the inhibitory effect elicited by selenium on ethylmorphine metabolism being prevented by phenobarbital.
Research communications in chemical pathology and pharmacology  •  1981  |  View Paper
It will be shown that the inductive effect of phenobarbitone on the microsomal drug-metabolizing enzyme system of normal rats is accompanied by a large increase in the uptake of selenium and its conversion to selenide; when vitamin E is withdrawn from the diet, this effect cannot be demonstrated.
The American journal of clinical nutrition  •  1974  |  View Paper