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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenobarbital
supplement:
Quinine
Research Papers that Mention the Interaction
“Mean urinary recoveries of carbamazepine, phenobarbitone and phenytoin over 24 hours also profoundly increased with concomitant administration of quinine.”
“These results indicate possible interaction between quinine and carbamazepine or phenobarbitone.”
Pharmacokinetic interaction of single doses of quinine and carbamazepine, phenobarbitone and phenytoin in healthy volunteers.“ Quinine increased sleeping time in phenobarbitalstimulated and unstimulated mice and in rats, decreased the ld 50 of pentobarbital in mice, and increased the plasma half-life of pentobarbital in goats.”
“Human liver metabolizes quinine in the microsornal fraction, but the plasma clearance of quinine in vivo was only slightly altered by phenobarbitone in the dosage of 125 milligrams (mg)/day for 3 days.”
“Plasma clearance of quinine in the rat is also increased by phenobarbitone treatment and decreased by feeding a purified protein free diet.”
“Diazepam and phenobarbitone significantly protected mice against convulsions induced by quinine.”
Effects of some GABAergic agents on quinine-induced seizures in mice
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