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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenobarbital
supplement:
Progestins
Research Papers that Mention the Interaction
“ Phenobarbital (phenobarbitone), phenytoin, carbamazepine, oxcarbazepine, felbamate and topiramate have been shown to increase the metabolism of ethinylestradiol and progestogens.”
Interactions Between Antiepileptic Drugs and Hormonal Contraception“The influence of drug stimulated biotransformation on the biological effectiveness of two different contraceptives (Deposition and Gravistat) was observed.- Phenobarbital , a potent enzyme inducer, is known to increase the metabolism of steroid hormones, including estrogens and progrestogens. --”
“Some antiepileptic drugs (e.g., phenytoin, phenobarbital , carbamazepine, and paramethadione) may cause more rapid metabolism of the progestin or estrogen component of combined oral contraceptives.”
Epilepsy drugs may reduce method effectiveness.
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