Possible Interaction: Phenobarbital and Potassium

“DEN and PB treatment significantly (P < 0.001) increased potassium , calcium and iron levels in serum, while it decreased (P < 0.001) the Se and sodium levels when compared with control rats.”

“In voltage clamped neurons, this concentration of phenobarbital significantly depressed the amount of potassium current inactivation without altering its time constant.”

“Abstract Pentobarbital (0.1 – 1.0 mM) and phenobarbital inhibit the uptake of potassium ions into astrocytes.”

“The rate of clearance of excess potassium from extracellular fluid is slower for high concentrations than for low; this rate is further slowed by the administration of phenobarbital , and possibly also of diphenylhydantoin.”

“These data suggest that a selective and reversible increase in membrane permeability to potassium is a principal direct effect of phenobarbital on this particular neuron.”

“Malonate (1 mM), pentobarbital (0.5 … decrease the potassium uptake, and phenobarbital (0.5 mM), chlorpromazine (0.01 mM), atropine (1 mM), and procaine (0.1 mM), which have no … action of 3.6 mM potassium on respiration and markedly reduce the large stimulatory effect of 60 mM potassium.”