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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenobarbital
supplement:
Polypeptides
Research Papers that Mention the Interaction
“The levels of the two mRNAs encoding these polypeptides were increased substantially upon phenobarbital administration.”
Isolation and characterization of cDNA clones for cytochromes P-450 immunochemically related to rat hepatic P-450 form PB-1.“The amount of functional mRNA specific for the P-450 polypeptides increases dramatically in response to an acute administration of phenobarbital ; however, in untreated rats the amount of functional mRNA was below the level of detection by the translational assay.”
“A number of major microsomal polypeptides which might represent unidentified forms of cytochrome P-450 in untreated males and females were markedly decreased in a specific manner as a result of phenobarbital and/or 3-methylcholanthrene treatments.”
“Noncoplanar isomers and PB induced the synthesis of a polypeptide of approximate 51,000 daltons.”
“Administration of phenobarbital , or of benzo[a]pyrene or 3-methylcholanthrene, resulted in specific increases of membrane polypeptides corresponding to cytochrome P-450 and cytochrome P-448 species respectively.”
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