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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenobarbital
supplement:
Phosphatidylethanolamine
Research Papers that Mention the Interaction
“These data demonstrate that phenobarbital pretreatment is associated with a shift in the predominant phospholipid locus from phosphatidylserine to phosphatidylethanolamine for the early CCl4-induced fatty acid changes in rat liver microsomes.”
Phenobarbital pretreatment alters the localization of CCl4-induced changes in rat liver microsomal fatty acids.“The treatment with phenobarbital constantly results in a decrease of the unsaturation index of fatty acids both in lecithins and cephalins.”
“Treatment with phenobarbital for 4 days also caused a significant increase of phosphatidylcholine and phosphatidylethanolamine content in plasma membranes.”
“The fatty acid content of phosphatidylethanolamine was increased by phenobarbital , mainly manifesting in palmitoleic, oleic, linoleic, arachidonic, docosapentenoic, and docosahexenoic acids.”
“ Phenobarbitone caused the proportion of linoleic acid in phosphatidylcholine and phosphatidylethanolamine to increase to 120-125% of the control and the proportion of oleic acid, arachidonic acid and docosahexaenoic acid to decrease.”
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