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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Phenobarbital and Iron, Dietary

Research Papers that Mention the Interaction

The present results indicate that iron plays a role in the development of preneoplastic foci in the livers of rats initiated with DEN and promoted by PB especially in the initiation phase.
British Journal of Cancer  •  1991  |  View Paper
Treatment of rats with phenobarbital PB ) caused simultaneous increase of cytochrome P450 and decrease of nonheme, nonferritin iron.
Archives of biochemistry and biophysics  •  1989  |  View Paper
Second, depletion of nonheme, nonferritin iron by pretreatment of rats with phenobarbital decreased the stimulation of lipid peroxidation by ADP.
Archives of biochemistry and biophysics  •  1989  |  View Paper
In vivo the absorption of Fe 59 SO 4 was significantly increased in phenobarbital-treated rats compared to controls (20.4 ± 5.7 versus 9.8 ± 4.2%; P P P 0.001).
Since there is evidence indicating that phenobarbital induces an increase in intestinal microsomal proteins and enzymes, it was postulated that phenobarbital might affect iron absorption by increasing the synthesis of a carrier protein for iron.
Gastroenterology  •  1972  |  View Paper