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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenobarbital
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“The present results indicate that iron plays a role in the development of preneoplastic foci in the livers of rats initiated with DEN and promoted by PB especially in the initiation phase.”
Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital.“Treatment of rats with phenobarbital PB ) caused simultaneous increase of cytochrome P450 and decrease of nonheme, nonferritin iron.”
“Second, depletion of nonheme, nonferritin iron by pretreatment of rats with phenobarbital decreased the stimulation of lipid peroxidation by ADP.”
“In vivo the absorption of Fe 59 SO 4 was significantly increased in phenobarbital-treated rats compared to controls (20.4 ± 5.7 versus 9.8 ± 4.2%; P P P 0.001).”
“Since there is evidence indicating that phenobarbital induces an increase in intestinal microsomal proteins and enzymes, it was postulated that phenobarbital might affect iron absorption by increasing the synthesis of a carrier protein for iron.”
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