supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Phenobarbital
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ PB induced persistent and transient increases in the intracellular calcium concentration.”
“Feeding PB decreased concentration of E2 and total plasma Ca in a dose- and period-dependent manner.”
“ Phenobarbital (0.04-0.12 mM) produced only depression of synaptic responses in CA 1 and dentate pathways.”
Barbiturate effects on hippocampal excitatory synaptic responses are selective and pathway specific.“Under these …, phenobarbital increased transmitter release in high external K+ (7.5 mM) (1.8 mM Ca++ , no Mg++) and in normal K+ (2.5 mM) (1.8 mM Ca++, no Mg++) to the same magnitude (130% of control) in contrast to the reported effects of primidone and PEMA.”
“Carbamazepine, phenobarbital , diazepam and lidocaine also inhibit veratridine- and K-stimulated Ca uptake, but ethosuximide and valproic acid are ineffective.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback