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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Phenobarbital and Alpha-Ketoglutarate

Research Papers that Mention the Interaction

After 30 min, phenobarbital decreased the concentrations of citric acid cycle intermediates (citrate, a-ketoglutarate , fumarate, malate and [calculated] oxaloacetate), as well as glutamate, and increased aspartate concentration.
Anesthesiology  •  1978  |  View Paper
Prior administration of phenobarbitone prevented the changes in a-ketoglutarate and in citric acid cycle metabolism in general.
Journal of neurochemistry  •  1974  |  View Paper
Sodium phenobarbital had an additive protective effect when it was administered together with the previously studied protective mixture (AGKO) containing arginine, glutamate, alpha-ketoglutarate , and oxalacetate.
[Technical report] SAM-TR. USAF School of Aerospace Medicine  •  1966  |  View Paper