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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenobarbital
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“After 30 min, phenobarbital decreased the concentrations of citric acid cycle intermediates (citrate, a-ketoglutarate , fumarate, malate and [calculated] oxaloacetate), as well as glutamate, and increased aspartate concentration.”
Influence of Phenobarbital Anesthesia on Carbohydrate and Amino Acid Metabolism in Rat Brain“Prior administration of phenobarbitone prevented the changes in a-ketoglutarate and in citric acid cycle metabolism in general.”
“ Sodium phenobarbital had an additive protective effect when it was administered together with the previously studied protective mixture (AGKO) containing arginine, glutamate, alpha-ketoglutarate , and oxalacetate.”
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