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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Phenindione and Vitamin K

supplement:

Vitamin K

Research Papers that Mention the Interaction

SEVERAL coumarin and indanedione drugs are capable of inducing hypoprothrombinæmia, presumably by interfering with the cofactor role of vitamin K in prothrombin synthesis.
Nature  •  1961  |  View Paper
Anatagonists of vitamin K —warfarin, phenylindanedione the 2-chloro analogue of vitamin K 1 , and tetrachloropyridinol—blocked prothrombin synthesis completely and without a lag period in the rat.
Molecular pharmacology  •  1974  |  View Paper