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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Phenformin
supplement:
Alpha-Ketoglutaric Acid
Research Papers that Mention the Interaction
“With all substrates studied, phenethylbiguanide decreases the steady state concentrations of fructose 6-phosphate and α-ketoglutarate , decreases the ATP:ADP ratio, decreases citric acid cycle activity, and causes both the mitochondrial and cytosolic oxidation-reduction states to be more reduced.”
Mode of action of hypoglycemic agents. V. Studies with phenethylbiguanide in isolated perfused rat liver.
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