Possible Interaction: Phenethylamines and Serotonin

“The finding that phenylethylamine and tryptamine are endogenous enhancers of the impulse propagation mediated release of catecholamines and serotonin in the brain, and the development of synthetic enhancer substances opened the possibility to stimulate catecholaminergic and serotonergic neurons in the brain stem via a previously unknown mechanism.”

“Methamphetamine and MDMA as well as similar substituted phenethylamines are toxic to DA and/or 5-HT neurons.”

“ Phenylethylamine administration influences other neurotransmitters such as dopamine, norepinephrine and 5-hydroxytryptamine.”

“Similarly, inhibition of PEA deamination occurred at a faster rate than that of 5-HT metabolism.”

“The phenethylamine derivatives , 4-fluoroamphetamine, 2-methylamino-3,4-methylene-dioxy-propiophenone (methylone), 1-(1,3-benzodioxol-5-yl)-2-butanamine (BDB), and N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB), had strong inhibitory effects on the re-uptake of dopamine, 5-HT and norepinephrine.”

“The results suggest (1) that phenylethylamine may exert its behavioural effects through increased release of both DA and 5-HT , and (2) that in vivo measurements of the acid metabolites alone may not be indicative of the release of the amines.”

“The increase in the release of serotonin in the dorsalis raphe nucleus caused by local application of parachlorophenylethylamine (10(-6) M) reduced striatal [3H]serotonin release.”

“Kinetic studies in mitochondrial preparations from both tissues of the rat showed that with both 5-HT and PEA as substrates the inhibition was of the competitive type when the enzyme preparation and the inhibitor were not preincubated prior to assay.”

“However, the fact that phenethylamine derivatives activate the serotonin uptake mechanism but do not induce platelet shape change suggests that serotonin uptake and serotonin-induced shape change are mediated by two distinct activation sites of serotonin receptors.”

“Abstract Administration of either indoleamine or phenylethylamine hallucinogens selectively increased the level of serotonin within cell bodies of both the dorsal and median raphe nuclei.”