Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Phenethylamines and Selegiline

Research Papers that Mention the Interaction

Selegiline administration increased phenylethylamine ( PEA ) urinary excretion and decreased urinary MHPG-sulfate concentration after cocaine when compared to cocaine alone.
BMC clinical pharmacology  •  2009  |  View Paper
Phenylethylamine concentrations are increased primarily by phenylalanine, its amino acid precursor and by such monoamine oxidase inhibitors as L-deprenyl and pargyline.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  1984  |  View Paper
This report describes a case of substance-induced depression and panic attacks associated with illegitimately obtained selegiline used in combination with the health supplement phenylethylamine (PEA).
Psychosomatics  •  2015  |  View Paper
Dopamine and 2‐phenylethylamine levels in striatal tissue are known to be increased after administration of selegiline (L‐deprenyl), but it is still difficult to explain why this treatment induces longevity or dopaminergic neuroprotection in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society  •  1993  |  View Paper
Similar results were obtained for (-)-deprenyl which, however, was more potent in inhibiting the deamination of phenethylamine than that of serotonin and tyramine.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Potentiation of the antiimmobility effects was observed when ineffective doses of PHEA and of DEP or MOC were administered in combination.
Pharmacology Biochemistry and Behavior  •  1998  |  View Paper
L-Deprenyl also caused an increase in phenylethylamine in the striatum and hypothalamus, but not in the neocortex.
Pharmacology Biochemistry and Behavior  •  1995  |  View Paper
Homogenates from animals pretreated with d l-deprenyl showed a decreased capacity to deaminate PEA , but not 5-MT or 5-HT.
Life sciences  •  1978  |  View Paper